The influence of the plantain juice on the manifestations and outcome of acute cyclophosphamide intoxication in rats
Abstract
To estimate the influence of the plantain juice on neurological manifestations of the severe acute cyclophosphamide intoxication, rats have been gavaged with 4 ml/kg plantain juice 1 h before cyclophosphamide dosing (intraperitoneally, 600 mg/kg). Within 3 h after cyclophosphamide administration, rats’ blood ammonia, glutamine and urea was increased. These alterations have been attenuated with the prophylactic administration of the plantain juice. At the background of the administration of the plantain juice the hypodynamia was less pronounced, duration of life has increased. Therefore, experimentally has been demonstrated the potency of the plantain juice usage for prophylaxis of hyperammonaemic and neurotoxic action of cyclophosphamide.
About the Authors
T. V. Schäfer
Научно-исследовательский испытательный институт (военной медицины) Военно-медицинской академии имени С.М. Кирова Минобороны России
Russian Federation
Russian Federation
J. J. Ivnitsky
Институт токсикологии ФМБА России
Russian Federation
Russian Federation
V. L. Rejniuk
Военно-медицинская академия имени С.М. Кирова Минобороны России
Russian Federation
Russian Federation
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Review
For citations:
Schäfer T.V., Ivnitsky J.J., Rejniuk V.L. The influence of the plantain juice on the manifestations and outcome of acute cyclophosphamide intoxication in rats. BIOpreparations. Prevention, Diagnosis, Treatment. 2015;(3):61-63. (In Russ.)
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