Analysis of Efficacy and Safety of Tick-Borne Encephalitis Vaccines
https://doi.org/10.30895/2221-996X-2018-18-1-33-41
Abstract
This article provides a review on efficacy and safety of tick-borne encephalitis vaccines licensed in the Russian Federation. It highlights that both Russian and imported tick-borne encephalitis vaccines demonstrate high immunogenicity, safety and epidemiological effectiveness in regions with high vaccine coverage. All licensed tick- borne encephalitis vaccines meet interchangeability criteria in terms of indications for use (with due regard to age limits), medical contraindications, vaccination schedules, vaccine composition, as well as safety, immunological activity and efficacy parameters. Timely and specific prophylaxis help reduce the incidence of tick-borne encephalitis in endemic regions.
About the Authors
T. Yu. Kozlova
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
1st Professional Category Expert of the Division for Evaluation of Antiviral Medicinal Immunobiological Products of the Centre for Evaluation and Control of Medicinal Immunobiological Products
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
L. M. Khantimirova
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Analyst of the Division for Evaluation of Antiviral Medicinal Immunobiological Products of the Centre for Evaluation and Control of Medicinal Immunobiological Products
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
A. V. Rukavishnikov
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Deputy Head of the Division for Evaluation of Antiviral Medicinal Immunobiological Products of the Centre for Evaluation and Control of Medicinal Immunobiological Products. Candidate of Biological Sciences
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
V. A. Shevtsov
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Head of the Division for Evaluation of Antiviral Medicinal Immunobiological Products of the Centre for Evaluation and Control of Medicinal Immunobiological Products. Candidate of Medicinal Sciences
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
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57. Orlinger KK, Hofmeister Y, Fritz R, Holzer GW, Falkner FG, Unger B, et al. А Tick-Borne Encephalitis Vaccine Based on the European Prototype Strain Induced Broadly Active Cross- Neutralization Antibodies in Humans. Journal of Infectious diseases 2011; 203: 1556–64.
58. Pavlova BG, Stavitskaya IV, Gorbunov MA, Shtukaturova OV, Pomogayeva AP, Stronin OV, et al. Immunization of Children and Adolescents with Inactivated Vaccines against Tick- Borne Encephalitis. BIOpreparations. Prevention, Diagnosis, Treatment 2003; (1): 24–8 (In Russ.)
59. Pavlenko EV, Leonova GN, Majstrovskaja OS. Comparative Study of the Immunogenicity of Vaccines against Tick-Borne Encephalitis. Dal’nevostochnyj Zhurnal Infekcionnoj Patologii 2007; 11: 56–62 (In Russ.)
60. Kollaritsch H, Paulke-Korinek M, Holzmann H, Hombach J, Bjorvatn B, Barrett A. Vaccines and Vaccination against Tick-Borne Encephalitis. Expert Rev Vaccines. 2012; 11(9): 1103–19.
61. Kharit SM, Ruleva AA, Fridman IV, Nacharova EP, Alekseeva LA, Vasil’eva GA, et al. The Results of an Open, Randomized Comparative Clinical Study to Assess the Reactogenicity, Safety and Immunogenicity of the Vaccine EntseVir in Children Aged 3 to 17 Years. Epidemiology&Vaccinal Prevention. 2015; 14(2): 66–72 (In Russ.)
62. Ankudinova AV, Romanenko VV, Vorovich MF, Kovtun OP, Esyunina MS, Kiktenko AV, et al. Results of a Clinical Immunogenicity and Safety Trial of Tick-E-Vac 0.25 ml Vaccine (Pediatric Dosage). The Vestnik Uralskoi Meditsinskoi Akademicheskoi Nauki 2014; 5(51): 64–9 (In Russ.)
63. Leonova GN, Ternovoi VA, Pavlenko EV, Maistrovskaya OS, Protopopova EV, Loktev VB. Evaluation of Vaccine Encepur Adult for Induction of Human Neutralizing Antibodies against Recent Far Eastern Subtype Strains of Tick-Borne Encephalitis Virus. Vaccine. 2007; 25(5): 895–901.
64. Afonina OS, Barkhaleva OA, Sarkisyan KA, Vorobieva MS, Movsesyants AA., Olefir YuV. The Study of Protective Properties of Vaccines against Virulent Strains of the Virus Tick-Borne Encephalitis Three Genotypes: European, Far Eastern and Siberian (Experimental Research). Epidemiology&Vaccinal Prevention. 2017; 1(92): 62–7 (In Russ.)
65. Leonova GN, Pavlenko EV. Characterization of Neutralizing Antibodies to Far Eastern of Tick–Borne Encephalitis Virus Subtype and the Antibody Avidity for Four Tick–Borne Encephalitis Vaccines in Human. Vaccine. 2009; 27(21): 2899–904.
66. Afonina OS, Terekhina LL, Barkhaleva OA, Ladyzhenskaya IP, Sarkisyan KA, Vorobieva MS, et al. Experimental Studies Cross Immune Response to Antigens of the Virus Strains of Tick-Borne Encephalitis Different Genotypes in Balb/C Mice, Immunized with Various Embodiments of Tick-Borne Encephalitis Vaccine. Epidemiology&Vaccinal Prevention. 2014; 5(78): 88–96 (In Russ.)
67. Orlinger KK, Hofmeister Y, Fritz R, Holzer GW, Falkner FG, Unger B, et al. А Tick-Borne Encephalitis Vaccine Based on the European Prototype Strain Induced Broadly Active Cross- Neutralization Antibodies in Humans. Journal of Infectious diseases 2011; 203: 1556–64.
68. Pavlenko EV, Leonova GN, Majstrovskaja OS. Comparative Study of the Immunogenicity of Vaccines against Tick-Borne Encephalitis. Dal’nevostochnyj Zhurnal Infekcionnoj Patologii 2007; 11: 56–62 (In Russ.)
Review
For citations:
Kozlova T.Yu., Khantimirova L.M., Rukavishnikov A.V., Shevtsov V.A. Analysis of Efficacy and Safety of Tick-Borne Encephalitis Vaccines. BIOpreparations. Prevention, Diagnosis, Treatment. 2018;18(1):33-41. (In Russ.) https://doi.org/10.30895/2221-996X-2018-18-1-33-41
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