The effect of recombinant interferon alpha-2b on the relative content of CD56bright NK cells in the peripheral blood of pregnant women with chronic urogenital infections
Abstract
Physiological immunodeficiency during pregnancy contributes to activation of chronic urogenital pathology which often causes intrauterine infections. Recombinant interferon-alpha based rectal suppositories VIFERON® are often used in Russia for treatment of pregnant women with urogenital pathology. The treatment results in a marked decrease in the number of pregnancy complications and perinatal pathology accompanied by a decrease in peripheral blood CD56bright natural killer cells.
About the Authors
E. N. Vyzhlova
Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N. F. Gamaleya
Russian Federation
Russian Federation
Senior researcher of the Laboratory of Ontogenesis and Interferon System Improvement. Candidate of Biological Sciences,
Gamalei st. 18, Moscow 123098
V. V. Malinovskaya
Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N. F. Gamaleya
Russian Federation
Russian Federation
Head of the Laboratory of Ontogenesis and Interferon System Improvement. Doctor of Biological Sciences, professor,
Gamalei st. 18, Moscow 123098
E. V. Dmitrieva
Federal Research Centre for Epidemiology and Microbiology named after the honorary academician N. F. Gamaleya
Russian Federation
Russian Federation
Researcher of the Laboratory of Ontogenesis and Interferon System Improvement. Candidate of Biological Sciences,
Gamalei st. 18, Moscow 123098
S. V. Novikova
Scientific Research Institute of Obstetrics and Gynecology of the Moscow Region
Russian Federation
Russian Federation
Head of the 2nd Obstetrics Hospital Unit. Doctor of Medical Sciences,
Pokrovka st. 22a, Moscow 101000
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Review
For citations:
Vyzhlova E.N., Malinovskaya V.V., Dmitrieva E.V., Novikova S.V. The effect of recombinant interferon alpha-2b on the relative content of CD56bright NK cells in the peripheral blood of pregnant women with chronic urogenital infections. BIOpreparations. Prevention, Diagnosis, Treatment. 2017;17(1):54-58. (In Russ.)
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