Evaluation of Immunobiological Properties of Bordetella pertussis Vaccine Strains
https://doi.org/10.30895/2221-996X-2018-18-1-57-64
Abstract
The study performed as part of evaluation of immunobiological properties of Bordetella pertussis vaccine strains offered an opportunity to standardize pertussis bacterial mass based on the content of surface antigens — agglutinogens 1, 2 and 3. Certain levels of agglutinogens in seed lots were found to be capable of modifying the protective activity of pertussis vaccine. The heterogeneity of the bacterial strain population was reduced by applying selection criteria for colonies based on expression of agglutinogens. B. pertussis seed lots derived from vaccine strains that had undergone selection were sent to manufacturers of the pertussis component of DTP vaccine. Production of pertussis vaccine using a more homogenous bacterial mass that actively expresses agglutinogens 1, 2 and 3 made it possible to enhance immunogenic activity of the pertussis component of DTP vaccine. The safety of the whole-cell pertussis vaccine produced from the standardized seed lot was not compromised.
About the Authors
I. A. Alekseeva
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Chief Expert of the Laboratory of Toxoids and Antitoxic Products of the Testing Centre for Evaluation of Medicinal Immunobiological Products’ Quality. Doctor of Medical Sciences
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
O. V. Perelygina
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Head of the Laboratory of Toxoids and Antitoxic Products of the Testing Centre for Evaluation of Medicinal Immunobiological Products’ Quality. Candidate of Medical Sciences
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
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Review
For citations:
Alekseeva I.A., Perelygina O.V. Evaluation of Immunobiological Properties of Bordetella pertussis Vaccine Strains. BIOpreparations. Prevention, Diagnosis, Treatment. 2018;18(1):57-64. (In Russ.) https://doi.org/10.30895/2221-996X-2018-18-1-57-64
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