Efficacy and Safety of Cholera Vaccines
https://doi.org/10.30895/2221-996X-2018-18-1-42-49
Abstract
Cholera is an acute diarrheal disease caused by toxigenic strains of Vibrio cholerae O1 and O139 serogroups. It still remains a major global healthcare problem. According to WHO, about 100,000 people die from cholera every year, despite the modern methods of treatment, improvement in the quality of drinking water, sanitation and hygiene. In recent years, oral cholera vaccines have proved an effective tool for preventing and curbing cholera epidemics. According to the WHO Ending Cholera — A Global Roadmap, mass vaccination should help reduce the mortality resulting from cholera by 90 % worldwide by 2030 and eliminate the disease in 20 countries. The review outlines the main historical stages in the development of cholera vaccines: parenteral, chemical, inactivated and live oral vaccines. The paper compares active ingredients and excipients used in Dukoral®, mORC-VAX®, Shanchol®, Euvichol®, Vaxchora®, Oravacs® and the cholera bivalent chemical vaccine. The results of international multicenter clinical trials of oral inactivated, live and chemical cholera vaccines are analysed. Issues related to efficacy and safety studies of cholera vaccines are considered.
About the Authors
A. A. Goryaev
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Deputy Head of the Division for Expert Evaluation of Antibacterial Medicinal Immunobiological Products of the Centre for Evaluation and Control of Medicinal Immunobiological Products. Candidate of Biological Sciences
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
L. V. Sayapina
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Chief Expert of the Division for Expert Evaluation of Antibacterial Medicinal Immunobiological Products of the Centre for Evaluation and Control of Medicinal Immunobiological Products. Doctor of Medical Sciences
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
Yu. I. Obukhov
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Head of the Division for Expert Evaluation of Antibacterial Medicinal Immunobiological Products of the Centre for Evaluation and Control of Medicinal Immunobiological Products
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
V. P. Bondarev
Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Director of the Centre for Evaluation and Control of Medicinal Immunobiological Products. Doctor of Medical Sciences, Professor
8/2 Petrovsky boulevard, Moscow 127051, Russian Federation
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Review
For citations:
Goryaev A.A., Sayapina L.V., Obukhov Yu.I., Bondarev V.P. Efficacy and Safety of Cholera Vaccines. BIOpreparations. Prevention, Diagnosis, Treatment. 2018;18(1):42-49. (In Russ.) https://doi.org/10.30895/2221-996X-2018-18-1-42-49
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