biopreparatБИОпрепараты. Профилактика, диагностика, лечениеBiological Products. Prevention, Diagnosis, Treatment2221-996X2619-1156Scientific Centre for Expert Evaluation of Medicinal Productsbiopreparat-82Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВлияние рекомбинантного интерферона альфа-2b на относительное содержание CD56bright-популяции натуральных киллеров в периферической крови беременных женщин с урогенитальными инфекциямиThe effect of recombinant interferon alpha-2b on the relative content of CD56bright NK cells in the peripheral blood of pregnant women with chronic urogenital infectionsВыжловаЕ. Н.VyzhlovaE. N.

Старший научный сотрудник лаборатории онтогенеза и коррекции системы интерферона, канд. биол. наук

Senior researcher of the Laboratory of Ontogenesis and Interferon System Improvement. Candidate of Biological Sciences,

Gamalei st. 18, Moscow 123098

noemail@neicon.ruМалиновскаяВ. В.MalinovskayaV. V.

Руководитель лаборатории онтогенеза и коррекции системы интерферона, д-р биол. наук, профессор

Head of the Laboratory of Ontogenesis and Interferon System Improvement. Doctor of Biological Sciences, professor,

Gamalei st. 18, Moscow 123098

noemail@neicon.ruДмитриеваЕ. В.DmitrievaE. V.

Научный сотрудник лаборатории онтогенеза и коррекции системы, канд. биол. наук 

Researcher of the Laboratory of Ontogenesis and Interferon System Improvement. Candidate of Biological Sciences,

Gamalei st. 18, Moscow 123098

ladyguinevere@mail.ruНовиковаС. В.NovikovaS. V.

Заведующая 2-м акушерским отделением, д-р мед. наук,

101000, Москва, ул. Покровка, 22а

Head of the 2nd Obstetrics Hospital Unit. Doctor of Medical Sciences,

Pokrovka st. 22a, Moscow 101000

noemail@neicon.ruФедеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н. Ф. ГамалеиРоссияFederal Research Centre for Epidemiology and Microbiology named after the honorary academician N. F. GamaleyaRussian FederationМосковский областной научно-исследовательский институт акушерства и гинекологииРоссияScientific Research Institute of Obstetrics and Gynecology of the Moscow RegionRussian Federation2017200220181715458Copyright © Выжлова Е.Н., Малиновская В.В., Дмитриева Е.В., Новикова С.В., 20182018Выжлова Е.Н., Малиновская В.В., Дмитриева Е.В., Новикова С.В.Vyzhlova E.N., Malinovskaya V.V., Dmitrieva E.V., Novikova S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.biopreparations.ru/jour/article/view/82

Ослабление неспецифической резистентности организма во время беременности сопровождается активацией хронических урогенитальных инфекций, которые являются частой причиной внутриутробного инфицирования плода. В российской акушерско-гинекологической практике в комплексе дородовой подготовки беременных с урогенитальными инфекциями применяется препарат на основе рекомбинантного интерферона альфа-2b ВИФЕРОН® в лекарственной форме «суппозитории ректальные». Благоприятный клинический эффект препарата на течение беременности и перинатальный исход сопровождается снижением относительного содержания CD56bright-популяции натуральных киллеров в периферической крови исследованных беременных женщин.

Physiological immunodeficiency during pregnancy contributes to activation of chronic urogenital pathology which often causes intrauterine infections. Recombinant interferon-alpha based rectal suppositories VIFERON® are often used in Russia for treatment of pregnant women with urogenital pathology. The treatment results in a marked decrease in the number of pregnancy complications and perinatal pathology accompanied by a decrease in peripheral blood CD56bright natural killer cells.

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The authors declare that there are no conflicts of interest present.