biopreparatБИОпрепараты. Профилактика, диагностика, лечениеBiological Products. Prevention, Diagnosis, Treatment2221-996X2619-1156Scientific Centre for Expert Evaluation of Medicinal Productsbiopreparat-49Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESИсследование фармакодинамики препарата на основе терапевтических гуманизированных моноклональных антител против интерлейкина-17 на модели антиген-индуцированного артрита на кроликахThe study of pharmacodynamics of a medicine based on humanized monoclonal antibodies against IL-17 in rabbit model of antigen-induced arthritisНедорубовА. А.NedorubovA. A.

Старший научный сотрудник отдела доклинических испытаний лекарственных средств

Senior researcher of the Department of preclinical trials of medicines

biocad@biocad.ruГрачевА. В.GrachevA. V.

Старший научный сотрудник отдела иммунохимии

Senior researcher of the Department of immunochemistry

noemail@neicon.ruВаравкоМ. А.VaravkoM. A.

Старший научный сотрудник отдела доклинических испытаний лекарственных средств

Senior researcher of the Department of preclinical trials of medicines

noemail@neicon.ruМорозоваЕ. Л.MorozovaE. L.

Руководитель отдела доклинических испытаний лекарственных средств

Head of the Department of preclinical trials of medicines

noemail@neicon.ruЗАО «БИОКАД»РоссияCJSC «BIOCAD»Russian Federation201620022018162101107Copyright © Недорубов А.А., Грачев А.В., Варавко М.А., Морозова Е.Л., 20182018Недорубов А.А., Грачев А.В., Варавко М.А., Морозова Е.Л.Nedorubov A.A., Grachev A.V., Varavko M.A., Morozova E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.biopreparations.ru/jour/article/view/49

В настоящей статье представлен материал по оценке специфического действия препарата терапевтических гуманизированных моноклональных антител против интерлейкина-17 на модели антиген-индуцированного артрита на кроликах. Исследована фармакокинетика и иммуногенность препарата анти-IL-17A. Тяжесть развития артрита оценивали по степени повреждения суставов, уровню маркеров воспаления и гистологической шкале Мэнкина.

The present article contains scientific data on the assessment of specific activity of therapeutic humanized monoclonal antibodies against IL-17 in rabbit model of antigen-induced arthritis. Pharmacokinetics and immunogenicity of anti-IL-17A preparation have been studied. The severity of rheumatoid arthritis progression has been assessed by the levels of joint damage, the levels of inflammatory markers and according to Menkin histological grade.

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The authors declare that there are no conflicts of interest present.