biopreparatБИОпрепараты. Профилактика, диагностика, лечениеBiological Products. Prevention, Diagnosis, Treatment2221-996X2619-1156Scientific Centre for Expert Evaluation of Medicinal Products10.30895/2221-996X-2018-18-1-33-41biopreparat-119Research ArticleОБЗОРЫREVIEWSАнализ эффективности и безопасности вакцин для профилактики клещевого энцефалитаAnalysis of Efficacy and Safety of Tick-Borne Encephalitis VaccinesКозловаТ. Ю.KozlovaT. Yu.

Эксперт 1-й категории управления экспертизы противовирусных МИБП Центра  экспертизы и контроля МИБП

Российская Федерация, 127051, Москва, Петровский бульвар, д. 8, стр. 2

1st Professional Category Expert of the Division for Evaluation  of Antiviral Medicinal Immunobiological Products of the Centre  for Evaluation and Control of Medicinal Immunobiological Products

8/2 Petrovsky boulevard, Moscow 127051, Russian Federation

KozlovaTU@expmed.ruХантимироваЛ. М.KhantimirovaL. M.

Аналитик управления экспертизы противовирусных МИБП Центра экспертизы и контроля МИБП

Российская Федерация, 127051, Москва, Петровский бульвар, д. 8, стр. 2

Analyst of the Division for Evaluation of Antiviral Medicinal  Immunobiological Products of the Centre for Evaluation and  Control of Medicinal Immunobiological Products

8/2 Petrovsky boulevard, Moscow 127051, Russian Federation

РукавишниковА. В.RukavishnikovA. V.

Заместитель начальника управления экспертизы противовирусных МИБП Центра экспертизы и контроля МИБП, канд. биол. наук

Российская Федерация, 127051, Москва, Петровский бульвар, д. 8, стр. 2

Deputy Head of the Division for Evaluation of Antiviral  Medicinal Immunobiological Products of the Centre for  Evaluation and Control of Medicinal Immunobiological Products. Candidate of Biological Sciences

8/2 Petrovsky boulevard, Moscow 127051, Russian Federation

ШевцовВ. А.ShevtsovV. A.

Начальник управления экспертизы противовирусных МИБП Центра экспертизы и контроля МИБП, канд. мед. наук

Российская Федерация, 127051, Москва, Петровский бульвар, д. 8, стр. 2

Head of the Division for Evaluation of Antiviral Medicinal  Immunobiological Products of the Centre for Evaluation and  Control of Medicinal Immunobiological Products. Candidate of Medicinal Sciences

8/2 Petrovsky boulevard, Moscow 127051, Russian Federation

Федеральное государственное бюджетное учреждение «Научный центр экспертизы средств медицинского применения» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationRussian Federation2018260320181813341Copyright © Козлова Т.Ю., Хантимирова Л.М., Рукавишников А.В., Шевцов В.А., 20182018Козлова Т.Ю., Хантимирова Л.М., Рукавишников А.В., Шевцов В.А.Kozlova T.Y., Khantimirova L.M., Rukavishnikov A.V., Shevtsov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.biopreparations.ru/jour/article/view/119

В статье приведен анализ эффективности и безопасности вакцин для профилактики клещевого энцефалита (КЭ), разрешенных для применения на территории Российской  Федерации. Показано, что используемые в настоящее время вакцины КЭ отечественного и  зарубежного производства обеспечивают высокую иммуногенность, безопасность и  эпидемиологическую эффективность в регионах с массовым охватом вакцинацией. Все зарегистрированные вакцины соответствуют основным принципам взаимозаменяемости по показаниям к применению с учетом возрастных ограничений, перечню медицинских противопоказаний, схемам вакцинации, составу вакцин, а также показателям безопасности, иммунологической активности и  эффективности. Своевременные меры специфической профилактики приводят к снижению заболеваемости КЭ в эндемичных регионах.

This article provides a review on efficacy and safety of tick-borne encephalitis vaccines licensed in the Russian Federation. It highlights  that both Russian and imported tick-borne encephalitis vaccines  demonstrate high immunogenicity, safety and epidemiological  effectiveness in regions with high vaccine coverage. All licensed tick- borne encephalitis vaccines meet interchangeability criteria in terms of  indications for use (with due regard to age limits), medical  contraindications, vaccination schedules, vaccine composition, as well as safety, immunological activity and efficacy parameters. Timely and  specific prophylaxis help reduce the incidence of tick-borne encephalitis  in endemic regions.

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The authors declare that there are no conflicts of interest present.